Ultima epistola?

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11 Anni 2 Settimane fa #210978 da ILBecchino
Risposta da ILBecchino al topic Re:Ultima epistola?

Io valuterei gli anticorpi antinucleo per confermare o eliminare l'ipotesi di lupus


Bene.....



The constellation of serositis, hypertension, diffuse lymphadenopathy, azotemia, and proteinuria in this patient was highly suspicious for a systemic autoimmune disease. Further laboratory workup revealed a positive result for antinuclear antibodies (ANA) 1:640, including those against double-stranded DNA (ds-DNA); IgG titer of 300 IU/mL, and an anti-Smith finding (156 EU/mL) which, when correlated with the clinical picture, are consistent with a diagnosis of systemic lupus erythematosus. Other relevant findings included a decreased complement level, with C3 and C4 levels of 46.2 mg/dL (0.462 g/L) and 5.3 mg/dL (0.053 g/L), respectively; a positive Coombs test; hypoalbuminemia (3.1 g/dL [31 g/L]); and a negative lupus anticoagulant antibody finding. Biopsy of the kidney was performed, which showed diffuse proliferative lupus nephritis class IV, with moderate activity and no chronicity;

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown cause that primarily affects the connective tissue. Because the disease affects the connective tissue, multiple organ systems, including the skin, joints, kidneys, lungs, nervous system, serous membranes, and/or other organs of the body are affected as well. As is typical of other autoimmune disorders, the immune system attacks the body’s own cells and tissue, which results in a continuous inflammatory response and tissue damage.

SLE is more common, and more severe, in nonwhite patients. The highest prevalence among ethnic groups is in blacks.[1] SLE is up to 10 times more common in women than in men and typically occurs during child-bearing age, with a peak age of onset between 15 and 45 years. The disease course is as variable as it is unpredictable, with periods of illness, or "flares," alternating with periods of remission. Estrogen may play a role in the pathophysiology of SLE, but this has not yet been proven conclusively. Women exposed to estrogen-containing OCPs, however, do have an increased risk of developing SLE, especially if they started using them recently.[2]

SLE is characterized by a wide spectrum of signs and symptoms due to the ongoing presence of a variety of antigens, auto-antibodies, and immune complexes, which result in accumulated tissue damage to the point of clinical manifestation. The American College of Rheumatology (ACR) diagnostic criteria for lupus includes 11 manifestations. These criteria include:

Serositis (pleuritis, pericarditis)
Oral ulcers
Arthritis (nonerosive)
Photosensitivity (exposure to UV radiation causes skin manifestations)
Blood dyscrasias (hemolytic anemia, leukopenia, thrombocytopenia)
Renal manifestations (proteinuria, casts)
Positive ANA finding
Immunologic disorders (anti-Smith antibodies positive, antiphospholipid antibody positive, false positive test for syphilis, presence of anti–double-stranded DNA antibodies)
Neurologic manifestations (seizures, focal signs, psychosis)
Malar (butterfly) rash
Discoid rash
The presence of 4 or more of these criteria, either serially or simultaneously, is diagnostic of SLE.[3] About 80% of patients have skin involvement manifesting as photosensitivity, malar (butterfly) and discoid rash (thick, red, scaly patches on the skin), ulcers in the oral and nasal cavities or in the vagina, or alopecia, all of which are part of ACR diagnostic criteria. However, an absence of skin manifestation, as described in this patient, should not lower clinical suspicion for lupus because its symptoms vary and come and go unpredictably. Diagnosing SLE can thus be elusive, with some patients suffering from unexplained symptoms of untreated SLE for years, such as the initial (and chronic) complaints of fever, malaise, joint pains, myalgias, and fatigue, as well as temporary loss of cognitive abilities.

When SLE is diagnosed, it is important to establish the severity and potential reversibility of the illness in order to institute appropriate therapy. Treatment options usually focus on the suppression of symptoms rather than treating the cause, since there is not an actual "cure" for the disease. Renal disease remains the most serious complication of SLE. It affects 30%-60% of patients.[4] Renal involvement is characterized by proteinuria (> 0.5 g/24h) and/or active urinary sediment (> 5 red blood cells per high-power field, pyuria, or cell casts). In patients with inactive sediment and > 500 mg/day of proteinuria, monitoring is recommended with urinalysis every 3-6 months for 3 years; every 3 months is preferred in patients with anti–double-stranded DNA antibodies and/or hypocomplementemia.[5]

Prompt renal biopsy is required in all lupus patients with evidence of kidney involvement to determine the histologic subtype of lupus nephritis.[6] The typical histologic picture is of a membranous glomerulonephritis, with "wire-loop" abnormalities that result from the granular appearance (on immunohistochemical staining) of immune-complex deposition along the glomerular basement membrane. The World Health Organization (WHO) classification of glomerulonephritis in SLE includes grades I to VI.[7] Pathology reports also reflect the extent of inflammatory (reversible) and chronic (irreversible scarring) changes. In general, treatment for lupus nephritis is not recommended in patients with class I or II disease or in those with extensive irreversible changes. In contrast, aggressive immunosuppression is recommended for patients with disease class III, IV, or V with inflammatory proliferative lesions, because a majority of those individuals, if untreated, develop end-stage renal disease (ESRD).[8] However, ESRD is seen in fewer than 5% of SLE cases, due to earlier detection and subsequent prompt management of the disease. Lupus nephritis tends to be an ongoing disease, with flares often requiring repeat biopsy and repeated treatment over time.

Pleural inflammation is a common feature of SLE and is the most common pulmonary manifestation of SLE. It causes chest pain, shortness of breath, and cough. Pleural effusions are typical findings and are usually ANA-positive exudates with low complement.[9] Less frequent pulmonary complications of SLE include interstitial lung disease and pulmonary hypertension.

The most common hematologic manifestation of SLE is anemia, usually normochromic normocytic, which is often overlooked in young menstruating women. Iron deficiency may also develop. Leukopenia and thrombocytopenia are common as well, which may be due to the primary disease process or may be a side effect of the subsequent pharmacologic treatment for the disease. Leukopenia almost always consists of lymphopenia, not granulocytopenia.[10] Patients with SLE may also have signs and symptoms of a thrombotic disorder known as antiphospholipid syndrome, wherein autoantibodies to phospholipids are present in the serum. Serum levels of anticardiolipin antibodies should also be checked in patients suspected of having SLE. The presence of these antibodies may result in a false positive test for syphilis. Lymphadenopathy is not an uncommon presentation in SLE; it occurs in 15%-26% of patients. However, diffuse lymphadenopathy is very rare and is reported in very few cases.[11,12] It is not one of the ACR criteria for the diagnosis of SLE. Lymph node biopsy may be warranted to exclude alternative diagnoses. The patient in this case underwent lymph node biopsy, which showed no evidence of lymphoproliferative disorder.

A number of research protocols (Systemic Lupus Activity Measure [SLAM], SLE Disease Activity Index [SLEDAI], etc) have been designed in order to accurately monitor disease activity,[13-15] which all use combinations of history, physical examination findings, and laboratory data. Meanwhile, the search for reliable markers of disease activity continues. Complement activation products, soluble T-cell activation markers, antibodies to C1q, and the use of nucleosomes have been reported but not validated for universal clinical use.[16] Currently, widely used indicators include anti–double-stranded DNA antibodies, complement levels, hemoglobin levels, platelet count, urine analysis, and serum levels of creatinine and albumin. Because there is great variability in SLE's presentation and course, predicting a flare in a particular patient should take into account laboratory findings that correlate with flares in the past.

Treatment of SLE is aimed at controlling acute flares and using maintenance strategies that suppress symptoms to an acceptable level, while preventing further organ damage. For milder manifestations of SLE, such as arthritis, dermatitis, and constitutional symptoms, NSAIDs, hydroxychloroquine, and low-dose steroids have been used with success. Severe forms of the disease, including those with more life-threatening courses (including lupus nephritis), require a combination therapy of high-dose systemic glucocorticoids and cyclophosphamide or mycophenolate mofetil to induce remission, followed by longer-term, intense immunosuppressive therapy to maintain response.[17]

The patient in this case began treatment with high-dose oral corticosteroids and mycophenolate mofetil. After 1 week, her condition improved, with significantly decreased shortness of breath. She was discharged to home with renal, rheumatologic, and primary care outpatient follow-up.

Prima di scavare una fossa, prepara bene il terreno.
Prima di seppelire un Cadavere accertati della sua morte. Prima di chiudere il cancello del cimitero controlla che siano usciti tutti....... i visitatori non i defunti

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11 Anni 2 Settimane fa #210992 da HelterSkelter
Risposta da HelterSkelter al topic Re:Ultima epistola?
SLE.... uff :beee:

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11 Anni 1 Settimana fa #211307 da Theli
Risposta da Theli al topic Re:Ultima epistola?
Becchino? (:

"In ogni caso, veniamo dal nulla e andiamo nel nulla, e non c'è nulla di cui preoccuparsi" (Peter Wessel Zapffe)

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11 Anni 1 Settimana fa #211365 da ILBecchino
Risposta da ILBecchino al topic Re:Ultima epistola?

Becchino? (:


Dica carissimo

Prima di scavare una fossa, prepara bene il terreno.
Prima di seppelire un Cadavere accertati della sua morte. Prima di chiudere il cancello del cimitero controlla che siano usciti tutti....... i visitatori non i defunti

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11 Anni 1 Settimana fa #211369 da Theli
Risposta da Theli al topic Re:Ultima epistola?

Becchino? (:


Dica carissimo


Quando la sua persona avrà tempo, potrà esporci qualche altro caso? (:

"In ogni caso, veniamo dal nulla e andiamo nel nulla, e non c'è nulla di cui preoccuparsi" (Peter Wessel Zapffe)

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11 Anni 1 Settimana fa #211374 da Cyanide
Risposta da Cyanide al topic Re:Ultima epistola?
Attendiamo con ansia (:

La violenza è l'ultimo rifugio degli incapaci (Isaac Asimov)

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11 Anni 1 Settimana fa #211375 da HelterSkelter
Risposta da HelterSkelter al topic Re:Ultima epistola?
concordo,,,,,, :drinks:

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10 Anni 11 Mesi fa #212029 da Propofol84
Risposta da Propofol84 al topic Re:Ultima epistola?
:teschio-

Sono TORNATA!!!  :mago:
Dopo MESI di latitanza, Propofol84, INDISCUSSA PRIMA ADEPTA de ILBecchino...si è ricollegata alla prestigiosa piattaforma!!!  :yahoo:

Mi stava sfuggendo il nome de ILBecchino...con tanto di apocope!  :skifus:
Becchi'...accontenta 'sti proseliti: svecchia 'sto topic e scrivi un nuovo caso. Poi, siccome questi nuovi discepoli (eccetto Theli) sono piccoli, si ingelosiscono se somministri quesiti alla sottoscritta su WLM!

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10 Anni 11 Mesi fa #212073 da ILBecchino
Risposta da ILBecchino al topic Re:Ultima epistola?

:teschio-

Sono TORNATA!!!  :mago:
Dopo MESI di latitanza, Propofol84, INDISCUSSA PRIMA ADEPTA de ILBecchino...si è ricollegata alla prestigiosa piattaforma!!!  :yahoo:

Mi stava sfuggendo il nome de ILBecchino...con tanto di apocope!  :skifus:
Becchi'...accontenta 'sti proseliti: svecchia 'sto topic e scrivi un nuovo caso. Poi, siccome questi nuovi discepoli (eccetto Theli) sono piccoli, si ingelosiscono se somministri quesiti alla sottoscritta su WLM!


Elenchi dettagliatamente,  ed in ordine cronologico, le numerose motivazioni che non hanno consentito la sua doverosa partecipazione al "tema" de Il becchino.
Se la mia nobilissima ed ancora più vetusta persona, qualora i fatti da lei adotti risultino congrui, riterrà opportuno reintegrala, in qualità di prima adepta, lo farà altrimenti......
saluti a lor signori.

Prima di scavare una fossa, prepara bene il terreno.
Prima di seppelire un Cadavere accertati della sua morte. Prima di chiudere il cancello del cimitero controlla che siano usciti tutti....... i visitatori non i defunti

Si prega Accedi o Crea un account a partecipare alla conversazione.

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10 Anni 11 Mesi fa - 10 Anni 11 Mesi fa #212106 da Propofol84
Risposta da Propofol84 al topic Re:Ultima epistola?


Elenchi dettagliatamente,  ed in ordine cronologico, le numerose motivazioni che non hanno consentito la sua doverosa partecipazione al "tema" de Il becchino.
Se la mia nobilissima ed ancora più vetusta persona, qualora i fatti da lei adotti risultino congrui, riterrà opportuno reintegrala, in qualità di prima adepta, lo farà altrimenti......
saluti a lor signori.


Ritengo che l'elenco di cui si fa richiesta non debba essere reso pubblico.  :P
Le motivazioni, se proprio ci tiene tanto, Le verranno elencate "dettagliatamente ed in ordine cronologico" in seno ad un contesto privato.  :scenic:

Sul fatto che la Sua pesona sia Nobilissima (Altissima forse no, Intelligentissima sicuramente sì  :angel: ) non ho mai avuto dubbi, ma è il "vetusta" che non mi convince: ILBecchino è giovane "inside" e non può aggrapparSi all'anagrafica per ribadire la Propria superiorità. Trovi altre scusa, Mae'!

QUESITO: che fine ha fatto la Donnagatto n° 2 (ex Micettina) ?
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